Claim: Stopping Tirzepatide abruptly without a plan can lead to a significant return of hunger and weight gain, as observed in clinical trials.
Verdict: Correct (75% confidence)
Explanation: According to a Tier 1 source, the SURMOUNT-4 trial observed that most adults with obesity who had tirzepatide withdrawn regained weight, supporting the claim that stopping the medication leads to weight gain (PMC). Drugs.com, a Tier 9 source, reports that participants regained about 14% of their lost weight within a year after stopping tirzepatide, further supporting the claim. Additionally, Endocrinology Advisor notes that withdrawal of tirzepatide is associated with at least 25% weight regain,...